Antineoplastic drug resistance and DNA repair
نویسندگان
چکیده
منابع مشابه
The role of DNA mismatch repair in drug resistance.
Loss of DNA mismatch repair (MMR) has been observed in a variety of human cancers. In addition to predisposing to oncogenesis, loss of MMR activity is of concern with respect to the use of chemotherapeutic agents to treat established tumors. Loss of MMR results in drug resistance directly by impairing the ability of the cell to detect DNA damage and activate apoptosis and indirectly by increasi...
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Loss of DNA mismatch repair occurs in many types of tumors. The effect of the loss of DNA mismatch repair activity on sensitivity to cisplatin and a panel of analogues was tested using two pairs of cell lines proficient or deficient in this function. HCT116+ch2, a human colon cancer cell line deficient in hMLH1, was 2.1-fold resistant to cisplatin and 1.3-fold resistant to carboplatin when comp...
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Humans are constantly exposed to diverse chemical and physical agents that have the potential to damage DNA, such as reactive oxygen species (ROS), ionizing radiation (IR), UV light, and various environmental, dietary or pollutant chemical agents. The integrity and survival of a cell is critically dependent on genome stability, and cells possess multi‐ ple pathways to repair these DNA lesions. ...
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BACKGROUND Surgery combined with chemotherapy is an important therapy for non-small cell lung cancer (NSCLC). However, chemotherapy drug resistance seriously hinders the curative effect. Studies show that DNA repair genes ERCC1 and BRCA1 are associated with NSCLC chemotherapy, but their expression and mechanism in NSCLC chemotherapy drug-resistant cells has not been elucidated. MATERIAL AND MET...
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In a model system employing Chinese hamster V-79 cells, the DNA synthesis inhibitor 3'-azido-3'-deoxythymidine (BW A509U, AZT) was shown to induce genome-wide DNA hypermethylation, low-frequency silencing of thymidine kinase (TK; EC 2.7.1.21) gene expression, and resistance to AZT. Twenty-four hours of exposure of V-79 cells to 150 microM AZT led to > 2-fold enhancement of genomic 5-methylcytos...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 1991
ISSN: 0923-7534
DOI: 10.1093/oxfordjournals.annonc.a057949